The best travel backpack for frequent travelers depends on your specific needs, preferences, and the type of travel you'll be doing. Here are a few highly regarded travel backpacks that are popular among frequent travelers:

1. Osprey Farpoint/Fairview Series:
   • The Osprey Farpoint (men's) and Fairview (women's) series are known for their comfort and versatility.
   • These backpacks come in various sizes and feature a zip-off daypack, making them suitable for both short trips and longer journeys.
   • The suspension system and padded straps offer comfort during extended wear.
2. Tortuga Setout Backpack:
   • The Tortuga Setout Backpack is designed with organization in mind, featuring a clamshell opening for easy packing and access.
   • It has a laptop compartment, multiple pockets, and a minimalist yet functional design.
   • The harness system best travel backpack for frequent travelers provides comfortable carrying, and it meets most airline carry-on size requirements.
3. Aer Travel Pack 2:
   • The Aer Travel Pack 2 is a sleek and streamlined option with a focus on organization and functionality.
   • It offers separate compartments for tech items, clothes, and accessories.
   • The sleek design and urban aesthetics make it a popular choice for city travel.
4. Peak Design Travel Backpack:
   • The Peak Design Travel Backpack is designed with innovative features like customizable dividers and expandable capacity.
   • It offers quick access to your gear and a modular system for organizing belongings.
   • The backpack's attention to detail and versatile layout make it a great choice for creative travelers.